I reach out to the VIPEr community with a few questions.
How familiar is anyone with using dibenzoyl peroxide as a catalyst for brominations with NBS?
If so did you use 75% remainder water or pure peroxide for the reactions?
We have been trying to reproduce the synthesis of a 2-bromo-methyl-indole derivative and the reaction is being incredibly finicky to us. We have ruled out almost every possibility except for the catalyst. Everyone uses dibenzoyl peroxide for this reaction but I have yet to find anyone who mentions the purity of what they are using. Any help anyone could offer would be greatly appreciated.