Exploring Proteins as Ligands using the Protein Data Bank

This in class activity is designed to introduce students to how amino acid side chains can coordinate metal ions in proteins.  It guides students through the exploration of several metal binding sites in proteins using the Ligand Explorer program on the Protein Data Bank (PDB) website.  Essentially, it is a way for them to use the PDB to “discover” the information generally presented on this topic in the introductory chapters of bioinorganic textbooks.  At the end it asks students to think about Hard Soft Acid Base theory and to see how that can be applied to the binding of metals in protei

Betsy Jamieson / Smith College Tue, 06/17/2014 - 15:23

Soluble Methane Monooxgenase Spectroscopy

Submitted by Gerard Rowe / University of South Carolina Aiken on Fri, 07/20/2012 - 09:37

Determining the reactive intermediates in metalloenzymes is a very involved task, and requires drawing from many different spectroscopies and physical methods.  The facile activation and oxidation of methane to produce methanol is one of the "holy grails" of inorganic chemistry.  Strategies exist within materials science and organometallic chemistry to activate methane, but using the enzyme methane monooxygenase, nature is able to carry out this difficult reaction at ambient temperatures and pressures (and in water, too!).

Modeling the FeB center in Bacterial Nitric Oxide Reductase: A Reading Guide

Submitted by Sheila Smith / University of Michigan- Dearborn on Fri, 02/24/2012 - 11:52

In 2011, I was fortunate to have Nicolai Lehnert come and speak to my bioinorganic class on his work modeling the FeB (non heme iron) center in bacterial Nitric Oxide reductase.  He suggested this paper to prepare the students for his talk and I developed this reading guide to help them (the students) get more out of the reading.

Exploding the Myth of Intracellular free metal ion pools_ A reading guide

Submitted by Sheila Smith / University of Michigan- Dearborn on Thu, 09/22/2011 - 15:18

This is a Reading guide to the Review article Transition Metal Speciation in the Cell: Insights from the Chemistry of Metal Ion Receptors Lydia A. Finney, et al. Science 300, 931 (2003);

DOI: 10.1126/science.1085049.  


Biological Inorganic Chemistry: Structure & Reactivity edited by Bertini, Gray, Stiefel, and Valentine

Submitted by Betsy Jamieson / Smith College on Tue, 07/20/2010 - 13:10

Biological Inorganic Chemistry:  Structure & Reactivity edited by Bertini, Gray, Stiefel, and Valentine was published by University Science Books (copyright 2007). It is a detailed text divided into 2 parts.  Part A gives "Overviews of Biological Inorganic Chemistry" while Part B goes into more specifics of "Metal Ion Containing Biological Systems."  Several prominent bioinorganic chemists have contributed chapters to the book in their various areas of expertise.