Trap-to-Trap Distillation of Volatile Organic Liquids (Polyhalomethanes)
Description
This lab exercise uses air-stable compounds (polyhalomethanes) to demonstrate trap-to-trap distillation, a technique used to separate air-sensitive compounds. The apparatus (including part numbers from CHEMGLASS) is described. In addition, slush baths are employed, which are a novelty for our Inorganic Laboratory course and a source of amazement for the students. The separation of the compounds (the percentage each compound in each trap) is determined by 1H NMR.
A Living Syllabus for Sophomore Level Inorganic Chemistry
Description
In my sophomore level inorganic course, I have experimented with the idea of a living syllabus as a way to develop my own specific learning objectives and to help the students connect the material to the tasks that will be expected of them in assessing their learning.
Suite of LOs on Biomimetic Modeling
This suite of activities can be used as a unit exploring the use of small molecule models and biophysical techniques to illuminate complicated biomolecules. The Parent LO: Modeling the FeB center in bacterial Nitric Oxide reductase is a short, data-filled and well-written article that is approachable with an undergraduate's level of understanding.
Five Slides About Magnetic Susceptibility
Description
This Five Slides About provides an overview of the concept of magnetic susceptibility for paramagnetic metal centers. Three methods are discussed, namely the Evans NMR Method, the magnetic balance and SQUID (Superconducting QUantum Interference Device). The availability of each method varies across institutions.
Employing 2D NMR and NOE to assign protons in an organometallic complex
Description
The following paper will be given to the students to study at home along with the questions in the attached document. Students will be allowed to discuss their answers in small groups and refine their answers, before the corresct answer is revealed.
The students will not need to see the actual spectra that are in the SI to be able to address the given questions, the spectra can be projected to the class when the answers of the student groups are discussed
Origins of Enantioselectivity during Allylic Substitution Reactions Catalyzed by Metallacyclic Iridium Complexes.
Modeling post-translational modification in cobalt nitrile hydratase with a metallopeptide from Anne Jones
Description
In this literature discussion, students read a paper about a cobalt metallopeptide that imitates the active site of the enzyme nitrile hydratase. Specifically, the model complex is oxidized by air to produce a coordination sphere with both cysteine thiolate and sulfinic acid ligands, much like the post-translationally oxidized cysteine ligands in the biological system.
Principles and imaging applications of CEST
Description
This five slides about chemical exchange transfer (CEST) discusses the magnetic properties of paramagnetic metal ions and their use as MR imaging agents. This includes tranditional contrast agents that affect the relaxation rate of nearby water protons and paramagnetic shift reagents suitable for CEST imaging applications. A recent redox-active cobalt complex is presented as an innovative agent for mapping redox imbalances in vivo.
Synthesis, Characterization, and Computational Modeling of [Co(acacen)L2]+, an Inhibitor of Zinc Finger Proteins
Description
In this experiment, students will synthesize a cobalt Schiff base complex with varying axial ligands ([Co(acacen)L2]+). They will characterize the complex using various techniques, and may perform computational modeling to predict spectroscopic properties.
Cobalt Schiff Base Zinc Finger Inhibitors
Description
This is a literature discussion based on the paper “Spectroscopic Elucidation of the Inhibitory Mechanism of Cys2