Ligand Lineup

Submitted by Sheri Lense / University of Wisconsin Oshkosh on Fri, 08/22/2014 - 11:40
Description

This is a kinesthetic activity in which students must utilize knowledge of the σ-donating, π-donating and π-accepting ability of ligands in order to rank the ligands in the spectrochemical series.  Students are each assigned a ligand on a card.  Suggested ligands are I-, Br-, Cl-, F-, ONO-, NO2- OH-, H2O, pyridine, NH3, ethylenediamine, bipyridine, phenanthroline, PPh3, CN- and CO.  Each student must evaluate the π-accepting, π-donating and σ-donating ability o

The Chemistry of Cooley's Anemia: A Case Study

Submitted by Chris Bailey / Wells College on Wed, 08/06/2014 - 11:36
Description

In this case study, information is presented to students in the form of a dialog between a physician and two parents who have just learned that their child has thalassemia (Cooley’s Anemia). The treatment for this disorder requires a lifetime commitment to whole blood transfusion and chelation therapy (both administered on a daily to weekly basis); the biggest obstacle to long term survival is patient non-compliance.

Nitrogen Fixation: A Structural Inorganic Mystery?

Submitted by Jodi O'Donnell / Siena College on Mon, 08/04/2014 - 16:17
Description

 

These slides describe the recent literature on the structure of the iron sulfur cluster of nitrogenase active site, FeMo-co.  Included are: a comparison of industrial vs. biological ammonia production, several crystal structures from the literature including the unknown until recently hypervalent carbon atom in the center, and a brief mention of the troubling sterics of the active site as crystallized.

A Living Syllabus for Sophomore Level Inorganic Chemistry

Submitted by Sheila Smith / University of Michigan- Dearborn on Mon, 08/04/2014 - 16:02
Description

In my sophomore level inorganic course, I have experimented with the idea of a living syllabus as a way to develop my own specific learning objectives and to help the students connect the material to the tasks that will be expected of them in assessing their learning. 

Isn't It Ionic (with apologies to Alanis Morissette)

Submitted by Craig M. Davis / Xavier University on Sun, 08/03/2014 - 16:58
Description

This spoof of the song "Isn't It Ironic" (by Alanis Morissette) summarizes the properties of ionic compounds in verse. Suitable for General Chemistry classes as well as Inorganic Chemistry, although a reference is made to the Born-Meyer equation.

C&E News as a Starting Point for Bioinorganic Literature Discussions

Submitted by Chris Bailey / Wells College on Mon, 07/28/2014 - 15:37
Description

This learning object consists of a bibliography of materials concerning bioinorganic chemistry which have appeared in C&E News over approximately the past 15 years (1999-2014). Many come from the Science and Technology Concentrates, some from News of the Week, others are full articles, and a few are letters to the editor. They cover a wide variety of bioinorganic topics. Also included are citations for the articles from the primary literature paper referred to in the respective C&E News articles.

The Structure and Function of Transferrin

Submitted by Chris Bailey / Wells College on Tue, 07/22/2014 - 14:51
Description

These Five Slides About examine the structure and function of the iron binding and transport protein transferrin. Students learn that transferrin also acts as an iron buffer and as a potential antimicrobial agent. The structure of the protein is explored in detail; it consists of a single polypeptide (80kDa) folded into two lobes, each of which can bind a single iron in a high affinity region. Changes in the protein as a result of iron uptake is discussed. The iron binding region and the requirement of a bidentate synergistic anion (carbonate) are examined.

The "Zinc Spark" - Zinc as a signaling chemical in life

Submitted by Kyle Grice / DePaul University on Sat, 07/19/2014 - 11:11
Description

This web resource is a TEDx talk about zinc and zinc's role in the early stages of the maturation of the egg. This would be a great introduction video for a gen chem, inorganic, or bioinorganic chemistry course. It introduces the idea that Zinc is stored in specific locations on the egg and then released all at the same time.

Utilizing the PDB and HSAB theory to understand metal specificity in trafficking proteins

Submitted by EGunn / Simmons College on Thu, 07/17/2014 - 15:19
Description

This is an in-class PDB exercise based on the paper "Mechanisms Controlling the Cellular Metal Economy" by Gilston and O'Halloran. Students are asked to visualize the metal binding sites of several proteins discussed in the paper, highlighting unusual metal geometries. After identifying the amino acid residues involved in metal binding, students will discuss the bond structure in terms of HSAB theory. 

Literature Discussion of "Mechanisms Controlling the Cellular Metal Economy"

Submitted by Kyle Grice / DePaul University on Thu, 07/17/2014 - 15:07
Description

This is a literature discussion of a review by Tom O'Halloran (The link to the paper is included in the "Web Resources" below). The review covers concepts of metal content in cells, metal trasport, storage, and regulation. Its a good review to start a broader or deeper discussion about metals in biology. We have provided some questions to help guide the student discussion. These questions can be given to students prior to coming to class, and the answers can either be used for the in-class discussion and/or collected.