17 Jul 2010

Medicinal Applications of Organometallic Compounds

In-Class Activity

Submitted by Sibrina Collins, The Charles H. Wright of Museum of African American History
This learning object focuses on concepts of bioorganmetallic chemistry. I use an article published in Chemical and Engineering News (Dagani, R. “The Bio Side of Organometallics,”Chem. Eng. News, 2002, 80(37), pp 23-29) to introduce students to this field. This activity consists of two components, namely writing a two-page summary of the article and using an in-class activity focused on the concepts of geometry, Crystal Field Theory (CFT) and proposing a mechanism for an overall chemical reaction.
Learning Goals: 
There are various goals for this assignment, which reinforces concepts the student has learned in previous courses.
1) The student will apply concepts from organic chemistry to propose reaction mechanisms.
2) The student will evaluate ligands not shown on the spectrochemical series and logically propose where the ligands should fit on the series.
3) The student will describe the geometry around the central metal ion in the organometallic compounds.
4) The student will write a two-page summary of the Chemical and Engineering News article and develop an appreciation of the field bioorganometallics.
Equipment needs: 
Implementation Notes: 
After an introduction to the topic of organometallics, I recommend having the students read the article over a weekend. Subsequently, during the following class period, distribute the handouts describing the activities. Have the students work in groups to complete the in-class activity. For a previous inorganic class, I had the students read the article and just provide a two paragraph summary for an exam. However, I don't believe that was an effective way to introduce the topic. Thus, I have now included an in-class activity to help reinforce concepts students have learned from earlier courses.
Time Required: 
One class period for the in-class activity.
Evaluation Methods: 
Evaluation Results: 
Creative Commons License: 
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