This is an overview of some important principles of ligand design. Topics covered include HSAB theory, the chelate effect, the chelate ring size effect, the macrocyclic effect, the cryptate effect, and steric focus in ligand design.
Students will be able to:
- identify how to best design a ligand to achieve a specific function
- evaluate how certain design characteristics can impact metal ion selectivity and complex stability
- infer what kinds of ligand design characteristic would be important in specific inorganic complexes
- observe the chelate effect
- observe the chelate ring effect
- observe enthalpic contributions in ligand systems
- observe the macrocyclic effect
- observe the cryptate effect
- observe the concept of steric focus in ligand design
These are some general rules for ligand design that are the result of my own personal research as well as topics I learned from my graduate advisor. This only serves as a general guideline and it should be noted that there are some exceptions to these rules (as is the case in most things we do in inorganic chemistry).