My Notes
Categories
This literature discussion explores a paper by the Que group that creates and characterizes spectroscopic and functional model complexes of non-heme iron halogenases.
| Attachment | Size |
|---|---|
| Non-Heme Iron Halogenases - In Class Discussion Qs.docx | 39.35 KB |
| Non-Heme Iron Halogenases - In Class Discussion Qs.pdf | 114.27 KB |
| Non-Heme Iron Halogenases - Pre-Class Reading Qs.docx | 38.42 KB |
| Non-Heme Iron Halogenases - Pre-Class Reading Qs.pdf | 107.97 KB |
Upon completion of this assignment, students will be able to:
- Read, analyze and summarize data and results from the primary literature
- Explain the rationale behind creating and studying model complexes of metalloenzymes
- Describe the active site structure, function, and mechanisms of alpha-KG-dependent non-heme iron enzymes
- Determine spin states of iron model complexes
- Interpret spectroscopic and kinetic data for non-heme iron model complexes
This article was used as a literature discussion in a Jr/Sr level special topics course on bioinorganic chemistry. Students were asked to read the article and then answer and submit the pre-class questions. During class, we reviewed their answers to the pre-class questions (in small groups and as a whole class), and then worked through the discussion questions (first in small groups, and then as a class).
Evaluation
Students were graded on completion for the pre-class questions, and a combination of completion and correctness for the in-class discussion questions, which were submitted the class period after the discussion.
Students did well on these assignments. Discussion of the spectroscopic data was the most challenging, and I provided an overview of those techniques both earlier in the semester and again as part of the class discussion.
Comments
Excellent pre-class and in-class assignments, Amanda.