This learning object was developed collaboratively by members of the IONiC Leadership Council. The overall goal is to provide a general overview of metals in biological systems and introduce students to several of the important ideas in the field of bioinorganic chemistry. Topics include toxic metals, metals used in biological systems and the overlap of these categories; issues associated with the uptake, transport and storage of metal ions; and the benefits gained by using metals in biological molecules.
The learning object includes a PowerPoint presentation (with various animations). There are notes included in the PowerPoint file for each slide providing additional background and details to introduce in class. For convenience, the notes from the PowerPoint file have also been placed in a separate Word document.
|Notes to Accompany the 5 Slides Bioinorganic Learning Object.doc||43.5 KB|
|updated ppt for mac catalina 2020||1.81 MB|
Learning goals for these slides include:
1. Students will be able to give examples describing the "problem" of metals in biology: lack of bioavailability, toxicity and the importance of getting it just right.
2. Students will be able to give three reasons (with specific examples) of why metal binding and transport is important.
Metals have to be accumulated in the body (you can't make metals and they're not naturally prevalent).
They must be stored in inert forms (because they're toxic).
They must be present above a threshold to support life (metals must get in and out).
3. Students can use their knowledge of VSEPR to describe structures likely in bioinorganic systems.
4. Students can use their knowledge of Lewis acid-base chemistry to describe reactivity in bioinorganic systems.
These slides could be used to give students a sense of the problems and benefits of using metals in biological systems as a way to introduce important ideas in bioinorganic chemistry. Many of the ideas, for example metal ion transport & storage, also have the potential to be expanded upon, with details from a text on bioinorganic chemistry or examples from the current literature.
Students could be asked to provide some of the information presented in the "Learning Goals" section above as part of an exam or quiz question.
This learning object was developed collaboratively by members of the Leadership Council who teach these topics in class regularly. In general, we have found that students are interested in learning how metals are used in biological systems. The issue of toxicity is always interesting since students do not always realize that you can have too much of a good thing (too much Fe can be toxic, for example). We have found that students enjoy seeing how topics they have already learned, like acid/base and redox chemistry, are applicable in biology.