Students are asked to read an article detailing the development of a cobalt-based MRI contrast agent ("A Redox-Activated MRI Contrast Agent that Switches Between Paramagnetic and Diamagnetic States", Tsitovich, P. B.; Spernyak, J. A.; Morrow, J. R. Angew. Chem. Int. Ed. 2013, 52, 14247-14250, DOI: 10.1002/anie.201306394). Before coming to class the students are asked to answer a series of questions designed to guide them through the first half of the article, and to be prepared to discuss their answers in class. During class, the answers of the questions are briefly reviewed before addressing a second set of questions in class.
1) Students explore the coordination geometry of a hexadentate N-donor ligand
2) Students pratice deriving a crystal field orbital diagram from the magnetic properies of Co(II)/Co(III) complexes
3) Student recognize and understand the origin of the differences of 1H-NMR spectra for paramagnetic and diamagnetic complexes
4) Students understand the basic principles of how a paraCEST contrast agent works, and develop a sense of how to decide on the suitability of a metal complex as a paraCEST contrast agent based on experimental data.
5) Students become more adept at interpreting representations of data
This reading guide accompanies A Redox-Activated MRI Contrast Agent that Switches Between Paramagnetic and Diamagnetic States, Tsitovich, P. B.; Spernyak, J. A.; Morrow, J. R. Angew. Chem. Int. Ed. 2013, 52, 14247-14250, DOI: 10.1002/anie.201306394
The LO is designed to help guide students through the reading of a scholarly article and prepare them for in-class discussion after completing the reading.