Students read two review articles and one research article on platinum-based cancer therapeutic agents. These articles compresentively discuss various aspects of these drug agents such as discovery, synthesis, mode of function. Students read the articles and use the knowledge on coordination chemistry (structure, reactivity, bonding, etc.) to explain the information included in the articles.
1) Mudiyanselage,R.; Rajapakse, G.; Dunuweera, S. P. Discovery, Chemistry, Anticancer Action and Targeting of Cisplatin. International Journal of Clinical Oncology and Cancer Research, 2017, 2, 65-74.
2) Takahara, P.; Rosenzweig, A. C.; Frederick, C. A.; Lippard, S. J. Crystal structure of double-stranded DNA containing the major adduct of the anticancer drug cisplatin. Nature 1995, 377, 649-652.
3) Cai, L.; Yu, C.; Ba, L.; Liu, Q.; Qian, Y.; Yang, B.; Gao, C. Anticancer platinum-based complexes with non-classical structures. Applied Organometallic Chemistry 2018, 32, e4228.
After completing the assignment, the students will be able to:
1. Explain the function and mechanism of platinum-based compounds as anti-cancer drugs.
2. Apply common concepts in coordination chemistry such as reaction mechanism, hard/soft acids and bases, crystal field stabilization energy, and chelating effect to explain the effectiveness of platinum-based cancer drugs.
The assignment has been implemented in my fundamental inorganic chemistry class for the past 2 years. The assignment was assigned toward the end of the coordination chemistry sections as a reading assignment, which is additional to homework assignments. Students have learned all basic concepts of coordination chemistry (structures, bonding, and reactions) by the time the assignment was assigned. Students have two weeks to read the three articles and submit the assignment.