This literature discussion focuses upon two journal articles by the Rebek group on the synthesis and host-guest chemistry observed with the "tennis ball."
After completing this literature discussion, students will be able to:
- provide examples of supramolecular systems in nature that use reversible, weak noncovalent interactions
- define terms in supramolecular chemistry such as host, guest, and self-complementary
- identify the number and location of hydrogen bonds within the "tennis ball" assembly
- draw common organic reaction mechanisms for the synthesis of the "tennis ball" subunits
- describe the physical and spectroscopic/spectrometric techniques used to provide evidence for assembly of a host-guest system
- explain the observed thermodynamic parameters that are important for encapsulation of small molecule guests by the "tennis ball"
This LO could be used at the end of a traditional 2-semester organic chemistry sequence as an introduction to organic supramolecular systems, as an organic chemistry example within a discussion about inorganic supramolecular chemistry, or in an upper-division elective course about supramolecular chemistry. The LO topic, the "tennis ball," has a published laboratory experiment in J. Chem. Educ. (found here). Time permitting, instructors could have students read the article and complete the literature discussion before executing the experiment in the lab.
As usual, instructors may wish to mix-and-match questions to suit their learning goals.