This study guide/question set will help a student navigate through the related research paper and test the student's understanding on the effects of hydrogen bonding in synthetic Cu-O2 adducts in the realm of bioinorganic model chemistry.
This LO is part of a special VIPEr collection honoring the 2021 ACS National Award recipients in the field of inorganic chemistry. Kenneth D. Karlin was the recipient of ACS Award for Distinguished Service in Advancement of Inorganic Chemistry for work for groundbreaking copper- and heme-dioxygen chemistry research and for a career encompassing service to the bioinorganic community, the ACS, and its Division of Inorganic Chemistry.
Students should be able to:
a) understand the roles of specific Cu centers in the essential enzymes and neurotransmitters such as PHM, DbM etc.
b) appreciate the mechanistic details pertaining to the stepwise reduction of dioxygen to water at a reduced Cu site.
c) rationalize how secondary sphere residues modulate the structural and reactivity aspects of Cu-O2 adducts in synthetic systems.
d) learn specific spectroscopic tools (UV-Vis, IR, EPR, Raman) implemented for such a study.
e) develop an appreciation of designing synthetic model complexes to study fundamental aspects of metalloenzymes.