17 Jul 2014

Cobalt Schiff Base Zinc Finger Inhibitors

Literature Discussion

Submitted by Peter Craig, McDaniel College

This is a literature discussion based on the paper “Spectroscopic Elucidation of the Inhibitory Mechanism of Cys2His2 Zinc Finger Transcription Factors by Cobalt(III) Schiff Base Complexes” by Heffern et. al. In Chemistry: A European Journal http://dx.doi.org/doi:10.1002/chem.201301659

Learning Goals: 

Students will be able to:


  1. read and comprehend the primary literature article
  2. name cobalt coordination complexes
  3. apply HSAB theory to cobalt(III)-Schiff base complexes and metal ion binding of zinc finger proteins
  4. apply the ligand spectrochemical series to determine the spin state of a cobalt(III)-Schiff base complex
  5. verbalize their answers to a series of questions and use these answers to develop answers to more detailed questions that arise during a discussion
  6. interpret and explain the results from various spectroscopies
Time Required: 
1 class period
Evaluation Methods: 

Collection of Reading Guide, evaluation of discussion

Evaluation Results: 

This LO was developed at the 2014 IONiC/VIPEr workshop Bioinorganic Applications of Coordination Chemistry and has not yet been evaluated.

Creative Commons License: 
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